Synthesis of agonists and atagonists for central glutamate receptors by a novel 'ring switching' strategy

Bowler, Andrew, Dinsmore, Andrew, Doyle, Paul M and Young, Douglas W (1997) Synthesis of agonists and atagonists for central glutamate receptors by a novel 'ring switching' strategy. Journal of the Chemical Society, Perkin Transactions 1, 9. 1297 - 1306. ISSN 0300-922X

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Abstract

A novel and versatile ring switching strategy has been developed for the synthesis of compounds with structural features consistent with activity at glutamate receptors. A variety of homochiral L-alanine derivatives substituted at the β-carbon atom with planar five and six-membered heteroaromatic rings have been prepared in a one- or two-pot reaction using this strategy and some of the products have been shown to have biological activity at central glutamate receptors.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: EPrints Services
Date Deposited: 06 Feb 2012 19:36
Last Modified: 06 Jun 2013 11:49
URI: http://sro.sussex.ac.uk/id/eprint/21440
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