Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease (NIFID)

Cairns, N J, Grossman, M, Arnold, SE, Burn, D J, Jaros, E, Perry, RH, Duyckaerts, C, Stankoff, B, Pillon, B, Skullerud, K, Cruz-Sanchez, F F, Bigio, E H, Mackenzie, I R, Gearing, M, Juncos, J L, Glass, J D, Yokoo, H, Nakazato, Y, Mosaheb, S, Thorpe, J R, Uryu, K, Lee, V M and Trojanowski, J Q (2004) Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease (NIFID). Neurology, 63 (8). pp. 1376-1384. ISSN 1526-632X

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Abstract

BACKGROUND: Recently described neuronal intermediate filament inclusion disease (NIFID) shows considerable clinical heterogeneity. OBJECTIVE: To assess the spectrum of the clinical and neuropathological features in 10 NIFID cases. METHODS: Retrospective chart and comprehensive neuropathological review of these NIFID cases was conducted. RESULTS: The mean age at onset was 40.8 (range 23 to 56) years, mean disease duration was 4.5 (range 2.7 to 13) years, and mean age at death was 45.3 (range 28 to 61) years. The most common presenting symptoms were behavioral and personality changes in 7 of 10 cases and, less often, memory loss, cognitive impairment, language deficits, and motor weakness. Extrapyramidal features were present in 8 of 10 patients. Language impairment, perseveration, executive dysfunction, hyperreflexia, and primitive reflexes were frequent signs, whereas a minority had buccofacial apraxia, supranuclear ophthalmoplegia, upper motor neuron disease (MND), and limb dystonia. Frontotemporal and caudate atrophy were common. Histologic changes were extensive in many cortical areas, deep gray matter, cerebellum, and spinal cord. The hallmark lesions of NIFID were unique neuronal IF inclusions detected most robustly by antibodies to neurofilament triplet proteins and alpha-internexin. CONCLUSION: NIFID is a neuropathologically distinct, clinically heterogeneous variant of frontotemporal dementia (FTD) that may include parkinsonism or MND. Neuronal IF inclusions are the neuropathological signatures of NIFID that distinguish it from all other FTD variants including FTD with MND and FTD tauopathies.

Item Type: Article
Additional Information: JT directed the research of his postgraduate student, Sabrina Mosaheb, which provided data necessary to help define the unique, distinguishing hallmark lesions of this novel frontotemporal dementia, `NIFID'. This article was chosen as the subject of the editorial in the journal issue, as it described a novel neurological disease entity.
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: EPrints Services
Date Deposited: 06 Feb 2012 19:35
Last Modified: 30 Nov 2012 17:04
URI: http://sro.sussex.ac.uk/id/eprint/21407
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