Compounds which potentiate the AMPA receptor and uses thereof in medicine

Glaxo Group Ltd; Bertheleme, Nicolas; Chan, Wai N; Scott, Jacqueline S; Ward, Simon E (2009) Compounds which potentiate the AMPA receptor and uses thereof in medicine. PCT/EP2008/067681.

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Abstract

Compounds of formula (I) and salts thereof are provided: wherein n is 0, 1, 2 or 3; R1 is selected from phenyl and pyridyl, each of which is optionally substituted by one or two groups independently selected from C1-4alkyl and halogen; and R2 is selected from H and CH3 when n is 1 and R2 is H when n is 2 or 3. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.

Item Type: Patent
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Simon Ward
Date Deposited: 06 Feb 2012 19:33
Last Modified: 25 Jul 2012 08:02
URI: http://sro.sussex.ac.uk/id/eprint/21227
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