posted on 2023-06-07, 14:58authored byClaire M. Connell, Rita Colnaghi, Sally P. Wheatley
Survivin is an essential mitotic protein that is overexpressed in many cancers, and its presence is correlated with increased resistance to radiation and chemotherapy. Here we demonstrate that sending survivin into the nucleus accelerates its degradation in a cdh1-dependent manner, abolishes the radio resistance normally conferred to cells by its overexpression, and prevents survivin from inhibiting apoptosis without affecting its mitotic localization. Our data suggest that targeting survivin to the nucleus provides an efficient means of eliminating it from the cell and may prove a novel strategy in cancer treatment, particularly in combination with radiotherapy.
History
Publication status
Published
Journal
Journal of Biological Chemistry
ISSN
0021-9258
Publisher
American Society for Biochemistry and Molecular Biology