Nuclear survivin has reduced stability and is not cytoprotective

Connell, Claire M., Colnaghi, Rita and Wheatley, Sally P. (2008) Nuclear survivin has reduced stability and is not cytoprotective. Journal of Biological Chemistry, 238 (6). pp. 3289-3296. ISSN 0021-9258

[img]
Preview
PDF
Download (643kB) | Preview

Abstract

Survivin is an essential mitotic protein that is overexpressed in many cancers, and its presence is correlated with increased resistance to radiation and chemotherapy. Here we demonstrate that sending survivin into the nucleus accelerates its degradation in a cdh1-dependent manner, abolishes the radio resistance normally conferred to cells by its overexpression, and prevents survivin from inhibiting apoptosis without affecting its mitotic localization. Our data suggest that targeting survivin to the nucleus provides an efficient means of eliminating it from the cell and may prove a novel strategy in cancer treatment, particularly in combination with radiotherapy.

Item Type: Article
Additional Information: Endnotes Ref: GDSC280
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Subjects: Q Science > QH Natural history > QH0301 Biology > QH0426 Genetics
Q Science > QH Natural history > QH0301 Biology
R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine
Depositing User: Gee Wheatley
Date Deposited: 26 Feb 2009
Last Modified: 12 Mar 2017 14:15
URI: http://sro.sussex.ac.uk/id/eprint/2122

View download statistics for this item

📧 Request an update