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Radioresistant glioma stem cells-Therapeutic obstacle or promising target?

journal contribution
posted on 2023-06-07, 14:57 authored by Anthony J Chalmers
Attempts to improve outcomes for patients with glioblastoma multiforme have focused largely on dose intensification and multimodal therapy and have been met with limited success. An alternative approach involves identifying and targeting the mechanisms responsible for tumour resistance. Recent data suggests that these high grade malignancies harbour a population of glioma stem cells that are both radioresistant and capable of initiating tumour regrowth. Furthermore, the radioresistant phenotype may be the consequence of constitutively upregulated and hyper-responsive cell cycle checkpoint pathways. This article considers whether these findings herald the dawn of a new era of effective, targeted therapy for this refractory tumour.

History

Publication status

  • Published

File Version

  • Published version

Journal

DNA Repair

ISSN

1568-7864

Publisher

Elsevier

Issue

9

Volume

6

Page range

1391-1394

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Notes

Endnotes Ref: GDSC267

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2009-03-23

First Compliant Deposit (FCD) Date

2018-03-22

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