Role of DNA Repair by Nonhomologous-End Joining in Bacillus subtilis Spore Resistance to Extreme Dryness, Mono- and Polychromatic UV, and Ionizing Radiation

Moeller, Ralf, Stackebrandt, Erko, Reitz, Günther, Berger, Thomas, Rettberg, Petra, Doherty, Aidan J, Horneck, Gerda and Nicholson, Wayne L (2007) Role of DNA Repair by Nonhomologous-End Joining in Bacillus subtilis Spore Resistance to Extreme Dryness, Mono- and Polychromatic UV, and Ionizing Radiation. Journal of Bacteriology, 189 (8). pp. 3306-3311. ISSN 0021-9193

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Abstract

The role of DNA repair by nonhomologous-end joining (NHEJ) in spore resistance to UV, ionizing radiation, and ultrahigh vacuum was studied in wild-type and DNA repair mutants (recA, splB, ykoU, ykoV, and ykoU ykoV mutants) of Bacillus subtilis. NHEJ-defective spores with mutations in ykoU, ykoV, and ykoU ykoV were significantly more sensitive to UV, ionizing radiation, and ultrahigh vacuum than wild-type spores, indicating that NHEJ provides an important pathway during spore germination for repair of DNA double-strand breaks.

Item Type: Article
Additional Information: From SRO Other External: E Stackebrandt, R Moeller, G Horneck, W L Nicholson
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Aidan Doherty
Date Deposited: 06 Feb 2012 19:31
Last Modified: 27 Apr 2012 13:58
URI: http://sro.sussex.ac.uk/id/eprint/21065
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