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Role of DNA Repair by Nonhomologous-End Joining in Bacillus subtilis Spore Resistance to Extreme Dryness, Mono- and Polychromatic UV, and Ionizing Radiation
journal contribution
posted on 2023-06-07, 23:14 authored by Ralf Moeller, Erko Stackebrandt, Günther Reitz, Thomas Berger, Petra Rettberg, Aidan DohertyAidan Doherty, Gerda Horneck, Wayne L NicholsonThe role of DNA repair by nonhomologous-end joining (NHEJ) in spore resistance to UV, ionizing radiation, and ultrahigh vacuum was studied in wild-type and DNA repair mutants (recA, splB, ykoU, ykoV, and ykoU ykoV mutants) of Bacillus subtilis. NHEJ-defective spores with mutations in ykoU, ykoV, and ykoU ykoV were significantly more sensitive to UV, ionizing radiation, and ultrahigh vacuum than wild-type spores, indicating that NHEJ provides an important pathway during spore germination for repair of DNA double-strand breaks.
History
Publication status
- Published
Journal
Journal of BacteriologyISSN
0021-9193Publisher
American Society for MicrobiologyExternal DOI
Issue
8Volume
189Page range
3306-3311Pages
6.0Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Notes
From SRO Other External: E Stackebrandt, R Moeller, G Horneck, W L NicholsonFull text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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