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Role of DNA Repair by Nonhomologous-End Joining in Bacillus subtilis Spore Resistance to Extreme Dryness, Mono- and Polychromatic UV, and Ionizing Radiation

journal contribution
posted on 2023-06-07, 23:14 authored by Ralf Moeller, Erko Stackebrandt, Günther Reitz, Thomas Berger, Petra Rettberg, Aidan DohertyAidan Doherty, Gerda Horneck, Wayne L Nicholson
The role of DNA repair by nonhomologous-end joining (NHEJ) in spore resistance to UV, ionizing radiation, and ultrahigh vacuum was studied in wild-type and DNA repair mutants (recA, splB, ykoU, ykoV, and ykoU ykoV mutants) of Bacillus subtilis. NHEJ-defective spores with mutations in ykoU, ykoV, and ykoU ykoV were significantly more sensitive to UV, ionizing radiation, and ultrahigh vacuum than wild-type spores, indicating that NHEJ provides an important pathway during spore germination for repair of DNA double-strand breaks.

History

Publication status

  • Published

Journal

Journal of Bacteriology

ISSN

0021-9193

Publisher

American Society for Microbiology

Issue

8

Volume

189

Page range

3306-3311

Pages

6.0

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Notes

From SRO Other External: E Stackebrandt, R Moeller, G Horneck, W L Nicholson

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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