Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists

Ward, Simon E, Eddershaw, Peter J, Scott, Claire M, Gordon, Laurie J, Lovell, Peter J, Moore, Susan H, Smith, Paul W, Starr, Kathryn R, Thewlis, Kevin M and Watson, Jeannette M (2008) Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists. Journal of Medicinal Chemistry, 51 (10). pp. 2887-2890. ISSN 0022-2623

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Abstract

5-HT1 receptor antagonists have been discovered with good selectivity over the 5-HT transporter. This is the first report of highly potent, selective ligands for the 5-HT1A/B/D receptors with low intrinsic activity, which represent a useful set of molecules for further understanding the roles of the 5-HT1 receptor subtypes and providing new approaches,for the treatment of depression.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science
Depositing User: Simon Ward
Date Deposited: 06 Feb 2012 19:30
Last Modified: 03 Oct 2012 12:43
URI: http://sro.sussex.ac.uk/id/eprint/20918
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