Galactose-phosphonates as mimetics of the sialyltransfer by trypanosomal sialidases

Busse, Heike, Hakoda, Mitsuru, Stanley, Matthew and Streicher, Hansjorg (2007) Galactose-phosphonates as mimetics of the sialyltransfer by trypanosomal sialidases. Journal of Carbohydrate Chemistry, 26 (3). pp. 159-194. ISSN 0732-8303

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Abstract

In an attempt to find competitive inhibitors of the trans- sialidase of the pathogen Trypanosoma cruzi, we have synthesized conjugates of carbocyclic sialylmimetics ( e. g., cyclohexenephosphonates) and galactose derivatives. A trans- sialidase inhibition assay revealed an interesting preference for ethylidene- spacered conjugates involving the 3- position of the sugar.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Mathew Stanley
Date Deposited: 06 Feb 2012 19:29
Last Modified: 23 Mar 2012 09:16
URI: http://sro.sussex.ac.uk/id/eprint/20794
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