Eldridge, S., Spencer, A., Cryer, C., Parsons, S., Underwood, M. and Feder, G. (2005) Why modelling a complex intervention is an important precursor to trial design: lessons from studying an intervention to reduce falls-related injuries in older people. Journal of Health Services Research and Policy, 10 (3). pp. 133-142. ISSN 1355-8196Full text not available from this repository.
Objectives: To develop a cost-effectiveness model of a complex intervention from pilot study data in order to inform the viability and design of a subsequent falls prevention trial. Methods: We used two models; the first estimated the probability of falling over a 12-month period based on a probability tree; the second used Markov simulation to assess the impact of the programme over time. Results: The first model indicated that our intervention would reduce the proportion falling by only 2.8% over a 12-month period. The major reason for this small effect was that less than a quarter of older people at risk of falling were assessed using our screening tool. Even if policy-makers were willing to spend £30,000 per quality-adjusted life-year gained, there is only a 40% chance that the intervention would be cost-effective. Sensitivity analyses showed that the only scenarios that produced a substantial increase in the effect of the intervention were those in which all older people are assessed. Conclusions: The model-building approach described in this paper is vital when designing complex trials and where a trial is not possible. Information from the modelling can be used to re-design the intervention. The effectiveness of our proposed intervention appears very small due to its inability to reach those at risk of falling. It is most likely not to be cost-effective. If inability to reach the target group is a weakness common to other similar interventions, this suggests an area for further research.
|Schools and Departments:||Brighton and Sussex Medical School > Primary Care and Public Health|
|Depositing User:||Jane Harle|
|Date Deposited:||21 Oct 2008|
|Last Modified:||30 Nov 2012 16:53|
|Google Scholar:||16 Citations|