X-Ray Diffraction Studies of Amyloid Structure

Makin, O Sumner and Serpell, Louise C (2004) X-Ray Diffraction Studies of Amyloid Structure. Methods in Molecular Biology, 299. pp. 67-80. ISSN 1064-3745

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Abstract

Elucidation of the underlying core structure of amyloid fibrils is essential for understanding the mechanism by which amyloid fibrils are formed and deposited. Conventional methods of X-ray crystallography and NMR cannot be used, since the fibers are insoluble and heterogeneous. X-ray fiber diffraction is one method that has been successfully used to examine the structure of these insoluble fibers. The procedure involves the formation of suitable, ordered amyloid fibrils and characterization (by electron microscopy), partial alignment of fibers, X-ray data collection, data analysis, and finally, model building.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Osmar Sumner Makin
Date Deposited: 06 Feb 2012 19:19
Last Modified: 20 Mar 2012 15:30
URI: http://sro.sussex.ac.uk/id/eprint/20070
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