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Increased association of telomerase with short telomeres in yeast

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posted on 2023-06-07, 14:51 authored by Alessandro BianchiAlessandro Bianchi, David Shore
Telomere function is mediated by the assembly of a protein complex on an array of telomeric DNA (TG) repeats synthesized by the telomerase enzyme. Telomerase action at chromosome ends is finely tuned by the telomeric complex so that a constant average number of repeats is maintained. This is achieved through a negative feedback process that is sensitive to TG tract length, but whose underlying mechanism is unknown. We show that short telomeres, which are preferential substrates for telomerase, display increased association with the enzyme in the S phase of the cell cycle, when telomerase acts. In addition, we provide support for a molecular mechanism by which this key step of telomerase recruitment is regulated by TG tract length.

History

Publication status

  • Published

File Version

  • Published version

Journal

Genes & Development

ISSN

0890-9369

Publisher

Cold Spring Harbor Laboratory Press

Issue

14

Volume

21

Page range

1726-1730

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2008-10-20

First Open Access (FOA) Date

2018-04-13

First Compliant Deposit (FCD) Date

2018-04-13

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