Imparied left ventricular systolic function early after heart transplantation is associated with cardiac allograft vasculopathy

Bolad, I A, Robinson, D R, Webb, C, Hamour, I, Burke, M M and Banner, N R (2006) Imparied left ventricular systolic function early after heart transplantation is associated with cardiac allograft vasculopathy. American Journal of Transplantation, 6 (1). pp. 161-168. ISSN 1600-6135

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Abstract

Cardiac allograft vasculopathy (CAV) is a major cause of death more than 1 year after heart transplantation. We evaluated the role and possible predictive value of different etiological factors on development of CAV as diagnosed by quantitative coronary angiography (OCA). A total of 121 patients were studied with baseline QCA and 117 had a follow-up study at 1 year to assess the relationship of mean lumen diameter loss (MLDL) in main coronary arteries to immunological and non-immunological factors potentially affecting long-term survival. Out of them, 103 patients were males (85%), 114 (94%) patients were Caucasians and mean age was 48.5 10 years. Univariate analysis showed that MLDL at 1 year was inversely related to echocardiographic fractional shortening (FS) measured within the first week after transplantation (p = 0.0098) and to intracranial hemorrhage as cause of donor death (p = 0.04) and was directly related to male donors (p = 0.0008), domino transplants (p = 0.037) and donor negative cytomegalovirus (CMV) status (p = 0.022). Multivariate analysis showed that initial FS (p = 0.006) and donor intracranial hemorrhage as a cause of death (p = 0.042) were inversely related to MLDL whereas donor male sex (p = 0.003) and prednisolone treatment throughout the first year (p = 0.012) were directly related. Thus, left ventricular systolic dysfunction early after heart transplantation was associated with subsequent development of CAV.

Item Type: Article
Schools and Departments: School of Mathematical and Physical Sciences > Mathematics
Depositing User: Derek Robinson
Date Deposited: 06 Feb 2012 19:16
Last Modified: 04 Apr 2012 08:23
URI: http://sro.sussex.ac.uk/id/eprint/19885
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