Effects of Epstein-Barr virus on host gene expression in Burkitt's lymphoma cell lines

Broderick, Peter, Hubank, Michael and Sinclair, Alison (2009) Effects of Epstein-Barr virus on host gene expression in Burkitt's lymphoma cell lines. Chinese Journal of Cancer, 28 (8). pp. 813-821. ISSN 1944-446X

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Abstract

BACKGROUND AND OBJECTIVE: Epstein-Barr virus (EBV) is present in Burkitt's lymphoma (BL) cells in a latent form, showing a highly restricted pattern of gene expression with few tumor cells undergoing viral lytic replication. BL cell lines can be induced to enter the viral lytic cycle and initiate replication by stimulating surface immunoglobulin molecules. During this process many EBV genes are expressed that have the potential to influence host gene expression. We aimed to identify host genes that are regulated by EBV in BL cells and those that are regulated following ligation of surface IgG.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Alison Sinclair
Date Deposited: 06 Feb 2012 19:15
Last Modified: 30 Mar 2012 14:17
URI: http://sro.sussex.ac.uk/id/eprint/19781
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