Endotoxin causes reciprocal changes in hepatic nitric oxide synthesis, gluconeogenesis, and flux through phosphoenolpyruvate carboxykinase

Horton, Robert A, Knowles, Richard G and Titheradge, Michael A (1994) Endotoxin causes reciprocal changes in hepatic nitric oxide synthesis, gluconeogenesis, and flux through phosphoenolpyruvate carboxykinase. Biochemical and Biophysical Research Communications, 204 (2). pp. 659-665. ISSN 0006291X

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Abstract

Treatment of rats with bacterial endotoxin resulted in a significant induction of hepatic nitric oxide synthase within 3 hours. The response was maximal at 12 hours and was maintained over 18 hours. The induction of nitric oxide synthase correlated well with the increase in plasma nitrate plus nitrite concentrations and also with the inhibition of glucose synthesis in subsequently isolated hepatocytes. The decline in the rate of gluconeogenesis also correlated with an inhibition of flux through phosphoenolpyruvate carboxykinase but not with alterations in flux through either pyruvate kinase or 6-phosphofructo-1-kinase, suggesting that a nitric oxide-induced inhibition of phosphoenolpyruvate carboxykinase may underlie the decreased glucose production in sepsis.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Michael Titheradge
Date Deposited: 06 Feb 2012 19:14
Last Modified: 22 Sep 2017 13:15
URI: http://sro.sussex.ac.uk/id/eprint/19703
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