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SUMO modification of proteins other than transcription factors

journal contribution
posted on 2023-06-07, 22:06 authored by Felicity Watts
A wide range of eukaryotic proteins has been shown to be sumoylated. Most, but not all of these proteins are nuclear. In all cases documented so far, sumoylation has been shown to occur on lysine residues. In general these are located within the consensus sequence ¿KxE, although there are some exceptions to this. The role of sumoylation has been investigated for a number of identified targets. Unlike the situation with ubiquitination, sumoylation does not appear to target proteins for proteasome-mediated degradation. In contrast, the effect of SUMO modification appears to depend on the target protein and includes roles in altering protein activity, protein-protein interactions or protein localisation.

History

Publication status

  • Published

Journal

Seminars in Cell & Developmental Biology

ISSN

10849521

Publisher

Elsevier

Issue

2

Volume

15

Page range

211-220

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Full text available

  • No

Peer reviewed?

  • No

Legacy Posted Date

2012-02-06

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