A convenient approach to (-)-8-epi-swainsonine

Murray, Adrian J and Parsons, Philip J (2006) A convenient approach to (-)-8-epi-swainsonine. Synlett, - (9). pp. 1443-1445. ISSN 09365214

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A novel and efficient synthesis of (-)-8-epi-swainsonine (2) is reported. Face-selective diol formation from the bicyclic alkene 3 followed by a stereoselective vinylation of the aldehyde and ring-closing metathesis gave the indolizidine ring system, which was converted into (-)-8-epi-swainsonine (2).

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Philip Parsons
Date Deposited: 06 Feb 2012 19:03
Last Modified: 21 Mar 2012 09:37
URI: http://sro.sussex.ac.uk/id/eprint/19158
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