Memory, cAMP, and PACAP-a phylogenetically conserved function? Studies in Lymnea stagnalis

Pirger, Z, Laszlo, Z, Hiripi, L, Reglodi, D, Lubics, A, Mark, L and Kemenes, G (2010) Memory, cAMP, and PACAP-a phylogenetically conserved function? Studies in Lymnea stagnalis. Journal of Molecular Neuroscience, 42 (3). p. 301. ISSN 0895-8696

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Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a highly conserved polypeptide, which, along with its receptors (PAC1-R, VPAC1, and VPAC2), is expressed in both vertebrate and invertebrate nervous systems. In the first part of the present study, we showed the presence of PACAP in Lymnea stagnalis by mass spectrometry and investigated whether PACAP elevates cAMP in cerebral ganglia. VIP, PACAP, and maxadilan increased cAMP levels by ~47, 79, and 82% of control levels, respectively, and this effect could be blocked by the co-application of the antagonist PACAP6-38 and maxadilan antagonist.

Item Type: Article
Additional Information: Part of the Proceedings of The International Symposium on VIP, PACAP and Related Peptides, OCT 05-08, 2009 Kagoshima, JAPAN
Schools and Departments: School of Life Sciences > Neuroscience
Depositing User: George Kemenes
Date Deposited: 06 Feb 2012 19:03
Last Modified: 30 Nov 2012 17:01
URI: http://sro.sussex.ac.uk/id/eprint/19088
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