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Memory, cAMP, and PACAP-a phylogenetically conserved function? Studies in Lymnea stagnalis

journal contribution
posted on 2023-06-07, 21:52 authored by Z Pirger, Z Laszlo, L Hiripi, D Reglodi, A Lubics, L Mark, George KemenesGeorge Kemenes
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a highly conserved polypeptide, which, along with its receptors (PAC1-R, VPAC1, and VPAC2), is expressed in both vertebrate and invertebrate nervous systems. In the first part of the present study, we showed the presence of PACAP in Lymnea stagnalis by mass spectrometry and investigated whether PACAP elevates cAMP in cerebral ganglia. VIP, PACAP, and maxadilan increased cAMP levels by ~47, 79, and 82% of control levels, respectively, and this effect could be blocked by the co-application of the antagonist PACAP6-38 and maxadilan antagonist.

History

Publication status

  • Published

Journal

Journal of Molecular Neuroscience

ISSN

0895-8696

Issue

3

Volume

42

Page range

301-301

Pages

1.0

Department affiliated with

  • Neuroscience Publications

Notes

Part of the Proceedings of The International Symposium on VIP, PACAP and Related Peptides, OCT 05-08, 2009 Kagoshima, JAPAN

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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