Fractal analysis of CE CT lung tumours images

Al-Kadi, O.S and Watson, D. (2007) Fractal analysis of CE CT lung tumours images. In: The 9th Great British R&D Show, London, UK.

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Abstract

AIM The fractal dimension (FD) of a structure provides a measure of its complexity. This pilot study aims to determine FD values for lung cancers visualised on Computed Tomography (CT) and to assess the potential for tumour FD measurements to provide an index of tumour aggression. METHOD Pre-and post-contrast CT images of the thorax acquired from 15 patients with lung cancers of greater than 10mm were transformed to fractal dimension images using a box-counting algorithm at various scales. A region of interest (ROI) was determined covering tumour locations, which were more apparent on FD images as compared to images before processing. The average tumour FD (FDavg) was computed and compared with the intensity average before FD processing. FD values were correlated with 2 markers of tumour aggression: tumour stage and tumour uptake of fluorodeoxyglucose (FDG) as determined by Positron Emission Tomography. RESULTS For pre-contrast images, the tumour FDavg correlated with tumour stage (r = 0.537, p = 0.0387) and FDG uptake (r= 0.64, p< 0.001). FDavg decreased following contrast enhancement for most tumours. CONCLUSION Fractal analysis of CT images of lung tumours could potentially provide additional information about likely tumour aggression and so impact on clinical management decisions and choice of treatment.

Item Type: Conference or Workshop Item (Poster)
Keywords: Fractal dimension, texture analysis
Schools and Departments: School of Engineering and Informatics > Informatics
Subjects: Q Science > QA Mathematics > QA0075 Electronic computers. Computer science
Q Science > QA Mathematics > QA0076 Computer software
Depositing User: Omar Al-Kadi
Date Deposited: 06 Oct 2009
Last Modified: 30 Nov 2012 16:53
URI: http://sro.sussex.ac.uk/id/eprint/1893
Google Scholar:0 Citations

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