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Combining a non-pyrethroid insecticide and a repellent: a new approach for controlling knockdown-resistant mosquitoes
journal contribution
posted on 2023-06-07, 21:31 authored by Cedric Pennetier, Vincent Corbel, Jean-Marc HougardAlthough pyrethroid-treated materials are a promising tool for the prevention and the control of dengue in the tropics, the development of pyrethroid resistance in the main mosquito vector (Aedes aegypti) may negate their use for personal and/or community protection. In that context, the efficacy of a mixture of a repellent (N,N-diethyl toluamide [DEET]) and a non-pyrethroid insecticide (propoxur) was investigated under laboratory conditions against both pyrethroid-susceptible and pyrethroid-resistant mosquitoes with the knockdown resistance (kdr) mutation. The results showed that a combination of propoxur and DEET induced a knockdown effect and mortality as high as deltamethrin (a standard pyrethroid) against the susceptible strain, and significantly higher efficacy against the pyrethroid-resistant strain. This could be explained mainly by the existence of a strong synergistic interaction between DEET and propoxur in mosquitoes. This study constitutes a first step towards an alternative strategy for improving mosquito control in areas with pyrethroid resistance.
History
Publication status
- Published
Journal
American Journal of Tropical Medicine and HygieneISSN
0002-9637Publisher
American Society of Tropical Medicine and HygienePublisher URL
Issue
6Volume
72Page range
739-744Department affiliated with
- Biology and Environmental Science Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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