DNA double-strand breaks: their cellular and clinical impact?

Jeggo, P A and Löbrich, M (2007) DNA double-strand breaks: their cellular and clinical impact? Oncogene, 26 (56). pp. 7717-7719. ISSN 0950-9232

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Abstract

DNA, the central store of our genetic information, constantly incurs damage from agents generated within the cell as well as chemicals or radiation that arise externally. Of the many different classes of damage, a DNA double-strand break (DSB) is arguably the most significant since, if unrepaired it can result in cell death and if misrepaired, it can cause chromosomal translocations, an early step in the aetiology of carcinogenesis. Endogenously generated reactive oxygen species primarily induce base damage and single strand breaks and it is unlikely that DNA DSBs are directly induced to any significant extent. However, DSBs may arise indirectly from two closely located single-strand breaks or during the repair of other lesions. They also arise when replication forks collapse, which may occur following the attempted replication of single-strand breaks or base damage. Indeed, a DSB is very likely the ultimate lesion induced by a wide range of DNA-damaging agents. The enhanced levels of endogenous chromosome breakage or chromosome rearrangements that have been observed in cells that fail to repair DSBs efficiently attests to the fact that they represent a relatively frequently encountered endogenous lesion (Karanjawala et al., 1999). Despite the constant onslaught of endogenous oxidative damage as well as frequently encountered exogenous DNA damage, genomic changes are a rare event and cells can undergo multiple rounds of replication without witnessing chromosomal alterations. This attests to the remarkable efficiency and evolutionary importance of the pathways that function in response to DSB induction.

Item Type: Article
Keywords: Animals *DNA Breaks, Double-Stranded DNA Repair DNA, Neoplasm/*genetics Humans Neoplasms/*genetics/metabolism/radiotherapy Recombination, Genetic Signal Transduction/*radiation effects
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Gee Wheatley
Date Deposited: 30 Sep 2008
Last Modified: 08 May 2018 11:29
URI: http://sro.sussex.ac.uk/id/eprint/1852
Google Scholar:44 Citations

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