Translesion synthesis: Y-family polymerases and the polymerase switch

Lehmann, Alan R, Niimi, Atsuko, Ogi, Tomoo, Brown, Stephanie, Sabbioneda, Simone, Wing, Jonathan F, Kannouche, Patricia L and Green, Catherine M (2007) Translesion synthesis: Y-family polymerases and the polymerase switch. DNA Repair, 6 (7). pp. 891-899. ISSN 1568-7864

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Replicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the replacement of the replicative polymerase by one of a group of specialised translesion synthesis (TLS) polymerases, most of which belong to the Y-family. Each of these has different substrate specificities for different types of damage. In eukaryotes mono-ubiquitination of PCNA plays a crucial role in the switch from replicative to TLS polymerases at stalled forks. All the Y-family polymerases have ubiquitin binding sites that increase their binding affinity for ubiquitinated PCNA at the sites of stalled forks.

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Alan Lehmann
Date Deposited: 06 Feb 2012 18:45
Last Modified: 30 Nov 2012 17:01
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