Recent Advances in the Discovery of Selective and Non-Selective 5-HT1D Receptor Ligands

Ward, Simon E and Watson, Jeannette M (2010) Recent Advances in the Discovery of Selective and Non-Selective 5-HT1D Receptor Ligands. Current Topics in Medicinal Chemistry, 10 (5). pp. 479-492. ISSN 1873-4294

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Abstract

This article highlights recent advances in the discovery of new agonists, antagonists and partial agonists of the 5-HT1D receptor. The field of 5-HT1D agonists continues to deliver a number of new potential therapeutic agents, although advances in this field are now more focussed on the clinical evaluation phase. The identification of novel compounds is greater for the 5-HT1D receptor antagonists, and whilst few truly selective ligands have been identified, a number of approaches are discussed towards defined mixed-pharmacology profiles. An overview is also given of recent advances in biological and clinical understanding of the receptor.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Simon Ward
Date Deposited: 06 Feb 2012 18:44
Last Modified: 19 Mar 2012 14:40
URI: http://sro.sussex.ac.uk/id/eprint/18078
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