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Recent Advances in the Discovery of Selective and Non-Selective 5-HT1D Receptor Ligands

journal contribution
posted on 2023-06-07, 21:11 authored by Simon E Ward, Jeannette M Watson
This article highlights recent advances in the discovery of new agonists, antagonists and partial agonists of the 5-HT1D receptor. The field of 5-HT1D agonists continues to deliver a number of new potential therapeutic agents, although advances in this field are now more focussed on the clinical evaluation phase. The identification of novel compounds is greater for the 5-HT1D receptor antagonists, and whilst few truly selective ligands have been identified, a number of approaches are discussed towards defined mixed-pharmacology profiles. An overview is also given of recent advances in biological and clinical understanding of the receptor.

History

Publication status

  • Published

Journal

Current Topics in Medicinal Chemistry

ISSN

1873-4294

Issue

5

Volume

10

Page range

479-492

Pages

14.0

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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