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Biotin-, fluorescein- and ‘clickable’ conjugates of phospha-oseltamivir as probes for the influenza virus which utilize selective binding to the neuraminidase

journal contribution
posted on 2023-06-07, 20:58 authored by Mathew Stanley, Max Birge, Stephen R Martin, Benoit Carbain, Hansjorg Streicher
The synthesis of conjugates of phospha-oseltamivir to the well established reporter groups fluorescein and biotin and an approach to multimeric inhibitors is described. We report powerful inhibition of the influenza neuraminidase by these probes and quantify fluorescence quenching during binding of the fluorescein conjugate through titration with the neuraminidase. Thus, we show that they could be useful tools to efficiently inhibit, detect and quantify the virus and the neuraminidase in biological systems.

History

Publication status

  • Published

Journal

Organic and Biomolecular Chemistry

ISSN

1477-0520

Publisher

Royal Society of Chemistry

Volume

9

Page range

5625-5629

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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