Increased association of telomerase with short telomeres in yeast

Bianchi, Alessandro (2007) Increased association of telomerase with short telomeres in yeast. Genes and Development, 21 (14). pp. 1726-1730. ISSN 08909369

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Abstract

Telomere function is mediated by the assembly of a protein complex on an array of telomeric DNA (TG) repeats synthesized by the telomerase enzyme. Telomerase action at chromosome ends is finely tuned by the telomeric complex so that a constant average number of repeats is maintained. This is achieved through a negative feedback process that is sensitive to TG tract length, but whose underlying mechanism is unknown. We show that short telomeres, which are preferential substrates for telomerase, display increased association with the enzyme in the S phase of the cell cycle, when telomerase acts. In addition, we provide support for a molecular mechanism by which this key step of telomerase recruitment is regulated by TG tract length.

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Depositing User: Alessandro Bianchi
Date Deposited: 06 Feb 2012 18:35
Last Modified: 17 Jul 2012 11:56
URI: http://sro.sussex.ac.uk/id/eprint/17300
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