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The folding and design of repeat proteins: reaching a consensus
journal contribution
posted on 2023-06-07, 20:38 authored by Ewan MainAlthough they are widely distributed across kingdoms and are involved in a myriad of essential processes, until recently, repeat proteins have received little attention in comparison to globular proteins. As the name indicates, repeat proteins contain strings of tandem repeats of a basic structural element. In this respect, their construction is quite different from that of globular proteins, in which sequentially distant elements coalesce to form the protein. The different families of repeat proteins use their diverse scaffolds to present highly specific binding surfaces through which protein-protein interactions are mediated. Recent studies seek to understand the stability, folding and design of this important class of proteins.
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Publication status
- Published
Journal
Current Opinion in Structural BiologyISSN
0959440XPublisher
ElsevierExternal DOI
Issue
4Volume
13Page range
482-9Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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