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The folding and design of repeat proteins: reaching a consensus

journal contribution
posted on 2023-06-07, 20:38 authored by Ewan Main
Although they are widely distributed across kingdoms and are involved in a myriad of essential processes, until recently, repeat proteins have received little attention in comparison to globular proteins. As the name indicates, repeat proteins contain strings of tandem repeats of a basic structural element. In this respect, their construction is quite different from that of globular proteins, in which sequentially distant elements coalesce to form the protein. The different families of repeat proteins use their diverse scaffolds to present highly specific binding surfaces through which protein-protein interactions are mediated. Recent studies seek to understand the stability, folding and design of this important class of proteins.

History

Publication status

  • Published

Journal

Current Opinion in Structural Biology

ISSN

0959440X

Publisher

Elsevier

Issue

4

Volume

13

Page range

482-9

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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