Dynamic clamp with StdpC software

Kemenes, Ildikó, Marra, Vincenzo, Crossley, Michael, Samu, Dávid, Staras, Kevin, Kemenes, György and Nowotny, Thomas (2011) Dynamic clamp with StdpC software. Nature Protocols, 6 (3). pp. 405-417. ISSN 1754-2189

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Abstract

Dynamic clamp is a powerful method that allows the introduction of artificial electrical components into target cells to simulate ionic conductances and synaptic inputs. This method is based on a fast cycle of measuring the membrane potential of a cell, calculating the current of a desired simulated component using an appropriate model and injecting this current into the cell. Here we present a dynamic clamp protocol using free, fully integrated, open-source software (StdpC, for spike timing-dependent plasticity clamp). Use of this protocol does not require specialist hardware, costly commercial software, experience in real-time operating systems or a strong programming background. The software enables the configuration and operation of a wide range of complex and fully automated dynamic clamp experiments through an intuitive and powerful interface with a minimal initial lead time of a few hours. After initial configuration, experimental results can be generated within minutes of establishing cell recording.

Item Type: Article
Schools and Departments: School of Engineering and Informatics > Informatics
Subjects: Q Science > QH Natural history > QH0301 Biology
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Depositing User: Ildiko Kemenes
Date Deposited: 06 Feb 2012 18:34
Last Modified: 14 Sep 2017 01:37
URI: http://sro.sussex.ac.uk/id/eprint/17184

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Project NameSussex Project NumberFunderFunder Ref
RCUK Academic FellowshipThomas NowotnyRCUKUnset