Synthesis, structural and biological studies of ubiquitin mutants containing (2S, 4S)-5-fluoroleucine residues strategically placed in the hydrophobic core

Alexeev, Dmitriy, Barlow, Paul N, Bury, Stella M, Charrier, Jean-Damien, Cooper, Alan, Hadfield, David, Jamieson, Craig, Kelly, Sharon M, Layfield, Robert, Mayer, R John, McSparron, Helen, Price, Nicholas C, Ramage, Robert, Sawyer, Lindsay, Starkmann, Bernard A, Uhrin, Dusan, Wilken, Jill and Young, Douglas W (2003) Synthesis, structural and biological studies of ubiquitin mutants containing (2S, 4S)-5-fluoroleucine residues strategically placed in the hydrophobic core. ChemBioChem, 4 (9). pp. 894-896. ISSN 1439-4227

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Item Type: Article
Additional Information: DWY is corresponding author and directed the synthetic work. The work reports the first ubiquitin variants in which selected leucine residues in the hydrophobic core have been replaced by (2S,4S)-5-fluoroleucine residues. Protein X-ray crystallographic, 19F-NMR and biophysical methods were used to show that protein folding was unafected.
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: EPrints Services
Date Deposited: 06 Feb 2012 18:33
Last Modified: 12 Jun 2012 15:02
URI: http://sro.sussex.ac.uk/id/eprint/17118
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