The timing of cochlear feedback: Spatial and temporal representation of a tone across the width of the guinea pig basilar membrane.

Nilsen, K E and Russell, I J (1999) The timing of cochlear feedback: Spatial and temporal representation of a tone across the width of the guinea pig basilar membrane. Nature Neuroscience, 2 (7). pp. 642-648. ISSN 10976256

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Abstract

Electromotile outer hair cell (OHC) feedback provides the sensitivity and sharp frequency tuning of the cochlea. Basilar membrane displacements in response to characteristic frequency (CF) tones were measured with an interferometer at up to 15 locations across the basilar membrane width in the basal turn of the guinea pig cochlea. For CF tones, basilar membrane vibrations were largest beneath the OHCs; these phase-led vibrations beneath outer pillar cells and adjacent to the spiral ligament by ~90°. Post mortem, responses measured beneath the OHCs were reduced by up to 65 dB, and the basilar membrane moved with similar phase across its entire width. We suggest OHCs amplify basilar membrane responses to CF tones when the basilar membrane moves at maximum velocity.

Item Type: Article
Schools and Departments: School of Life Sciences > Biology and Environmental Science
Depositing User: Ian Russell
Date Deposited: 06 Feb 2012 18:32
Last Modified: 20 Mar 2012 11:18
URI: http://sro.sussex.ac.uk/id/eprint/17037
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