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Replication fork arrest, recombination and the maintenance of ribosomal DNA stability

journal contribution
posted on 2023-06-07, 19:53 authored by Ellen Tsang, Antony CarrAntony Carr
There is increasing interest in the role of replication fork arrest and collapse in stimulating genomic instability. Changes in the copy number of the rDNA repeats mediated by homologous recombination has been linked to programmed replication fork barriers (RFBs) and this has been proposed to serve as a paradigm to help understand the links between replication and recombination. Here we review recent advances in our understanding of the initiation and regulation rDNA recombination and discuss historical observations in the context of recently developed models. We contrast the outcome of replication fork arrest at the rDNA RFB with those at an alternative RFB and suggest that, while there are potential similarities in response, there are also important differences which reflect the highly specialised nature of rDNA metabolism. (c) 2008 Elsevier B.V. All rights reserved.

History

Publication status

  • Published

Journal

DNA Repair

ISSN

1568-7864

Issue

10

Volume

7

Page range

1613-1623

Pages

11.0

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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