Electrical properties of breast cancer cells from impedance measurement of cell suspensions

Qiao, G, Duan, W, Chatwin, C, Sinclair, A and Wang, W (2010) Electrical properties of breast cancer cells from impedance measurement of cell suspensions. Journal of Physics: Conference Series, 224 (1). ISSN 1742-6588

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Abstract

Impedance spectroscopy of biological cells has been used to monitor cell status, e.g. cell proliferation, viability, etc. It is also a fundamental method for the study of the electrical properties of cells which has been utilised for cell identification in investigations of cell behaviour in the presence of an applied electric field, e.g. electroporation. There are two standard methods for impedance measurement on cells. The use of microelectrodes for single cell impedance measurement is one method to realise the measurement, but the variations between individual cells introduce significant measurement errors. Another method to measure electrical properties is by the measurement of cell suspensions, i.e. a group of cells within a culture medium or buffer. This paper presents an investigation of the impedance of normal and cancerous breast cells in suspension using the Maxwell-Wagner mixture theory to analyse the results and extract the electrical parameters of a single cell. The results show that normal and different stages of cancer breast cells can be distinguished by the conductivity presented by each cell. © 2010 IOP Publishing Ltd.

Item Type: Article
Additional Information: 14th International Conference on Electrical Bioimpedance, Held in Conjunction with the 11th Conference on Biomedical Applications of EIT, ICEBI and EIT 2010; Gainesville, FL; 4 April 2010 through 8 April 2010
Schools and Departments: School of Engineering and Informatics > Engineering and Design
Depositing User: Guofeng Qiao
Date Deposited: 06 Feb 2012 18:23
Last Modified: 07 Mar 2017 06:39
URI: http://sro.sussex.ac.uk/id/eprint/16059

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