How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex.

Bianchi, Alessandro and Shore, D (2008) How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex. Molecular Cell, 31 (2). pp. 153-165. ISSN 10972765

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Abstract

The telomerase enzyme, which synthesizes telomeric DNA repeats, is regulated in cis at individual chromosome ends by the telomeric protein/DNA complex in a manner dependent on telomere repeat-array length. A dynamic interplay between telomerase-inhibiting factors bound at duplex DNA repeats and telomerase-promoting ones bound at single-stranded terminal DNA overhangs appears to modulate telomerase activity and to be directly related to the transient deprotection of telomeres. We discuss recent advances on the mechanism of telomerase regulation at chromosome ends in both yeast and mammalian systems.

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
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Depositing User: Alessandro Bianchi
Date Deposited: 06 Feb 2012 18:22
Last Modified: 17 Jul 2012 10:30
URI: http://sro.sussex.ac.uk/id/eprint/16027
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