Minimal ionizing radiation sensitivity in a large cohort of xeroderma pigmentosum fibroblasts

Arlett, C F, Green, M H L, Rogers, P B, Lehmann, A R and Plowman, P N (2008) Minimal ionizing radiation sensitivity in a large cohort of xeroderma pigmentosum fibroblasts. British Journal of Radiology, 81 (961). pp. 51-58. ISSN 0007-1285

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Abstract

We have examined our ionizing radiation survival data for 33 xeroderma pigmentosum (XP) primary fibroblast lines and compared the data to that of 53 normal fibroblast lines, 7 Cockayne syndrome (CS) lines, 4 combined XP/CS lines and 8 ataxia-telangiectasia fibroblast lines. Although there are differences in radiosensitivity between cell lines within each class, we have no convincing evidence that XP lines as a group are more sensitive to ionizing radiation than the general population. However, because the XP phenotype may lead to premature ageing, especially of sun-exposed tissues, we would still advocate caution when XP patients come to radiotherapy. Our results confirm the extreme ionizing radiation hypersensitivity of ataxia-telangiectasia; they are also consistent with a tendency for slight hypersensitivity in CS, but not (necessarily) in combined XP/CS.

Item Type: Article
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
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Depositing User: Alan Lehmann
Date Deposited: 06 Feb 2012 18:21
Last Modified: 30 Nov 2012 16:59
URI: http://sro.sussex.ac.uk/id/eprint/15905
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