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Dynamical origin of independent spiking and bursting activity in neural microcircuits

journal contribution
posted on 2023-06-07, 14:18 authored by Thomas NowotnyThomas Nowotny, Mikhail I Rabinovich
The relationship between spiking and bursting dynamics is a key question in neuroscience, particularly in understanding the origins of different neural coding strategies, the mechanisms of motor command generation, and the process of neural circuit coordination. Experiments indicate that spiking and bursting dynamics can often be independent. We hypothesize that different mechanisms for spike and burst generation are the origin of this independence. If bursts result from a modulation instability of the network while spikes are produced by individual neurons, the bursting dynamics are independent of the details of the spiking activity. We tested this hypothesis in a detailed dynamical analysis of a minimal inhibitory neural microcircuit (motif) consisting of three reciprocally connected Hodgkin-Huxley neurons. We show that this high-dimensional system can be reduced to a time-averaged rate model and demonstrate that the H-H neural network and the rate model have identical bifurcations on the way from tonic spiking to burst generation. Burst generation in this system consequently does not depend on the details of spiking activity.

History

Publication status

  • Published

File Version

  • Published version

Journal

Physical Review Letters

ISSN

0031-9007

Publisher

American Physical Society

Issue

12

Volume

98

Page range

128106

Department affiliated with

  • Informatics Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2008-03-07

First Compliant Deposit (FCD) Date

2014-03-05

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