Mammalian single-strand break repair: Mechanisms and links with chromatin

Caldecott, Keith W. (2007) Mammalian single-strand break repair: Mechanisms and links with chromatin. DNA Repair, 6 (4: Rep). pp. 443-453. ISSN 1568-7864

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Abstract

Thousands of cellular single-strand breaks (SSBs) arise in cells each day, from attack of deoxyribose and DNA bases by reactive oxygen species and other electrophilic molecules, and from the intrinsic instability of DNA. If not repaired, SSBs can disrupt transcription and replication and can be converted into potentially clastogenic and/or lethal DNA double-strand breaks. Here, I present an updated model for the repair of SSBs, and speculate on the possible impact of chromatin structure and remodelling on single-strand break repair (SSBR) processes.

Item Type: Article
Keywords: Chromatin; Base excision repair; XRCCI; PARP; DNA strand break repair
Schools and Departments: School of Life Sciences
Subjects: Q Science > QH Natural history > QH0301 Biology
Depositing User: Chris Keene
Date Deposited: 15 Aug 2007
Last Modified: 30 Nov 2012 16:52
URI: http://sro.sussex.ac.uk/id/eprint/1545
Google Scholar:56 Citations
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