The short (S) allele of the serotonin transporter polymorphism and acute tryptophan depletion both increase impulsivity in men

Walderhaug, E, Herman, A I, Magnusson, A, Morgan, M J and Landrø, N I (2010) The short (S) allele of the serotonin transporter polymorphism and acute tryptophan depletion both increase impulsivity in men. Neuroscience Letters, 473 (3). pp. 208-211. ISSN 0304-3940

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Abstract

Reduced serotonergic neurotransmission is implicated in impulsive behavior. We studied the triallelic system of the serotonin transporter gene linked polymorphic region (5-HTTLPR) and acute manipulation of serotonin together to further delineate the mechanisms by which serotonergic neurotransmission affects impulsivity. Fifty-two healthy participants (38 men and 14 women) underwent acute tryptophan depletion (ATD) or placebo in a randomized, double-blind, parallel group experiment. Impulsive response style was measured on two versions of the Continuous Performance Task (CPT), and calculated using signal detection theory. We observed a dose-dependent effect for the short (S ) allele of the 5-HTTLPR on impulsive response style. Individuals who had the S /S genotype were more impulsive than individuals with the L/S genotype. Participants with the L/S genotype were more impulsive than those with the L/L genotype. ATD increased impulsivity in men, and decreased impulsivity in women. These data demonstrate for the first time that reduced serotonergic tone as a result of either 5-HTTLPR genotype, or experimental ATD, are both independently, and additively, associated with elevated impulsive response style in Caucasian men.

Item Type: Article
Additional Information: Collaborator and co-author
Schools and Departments: School of Psychology > Psychology
Depositing User: Michael Morgan
Date Deposited: 06 Feb 2012 15:50
Last Modified: 17 Jun 2013 08:25
URI: http://sro.sussex.ac.uk/id/eprint/14698
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