Deficits in sensory-specific devaluation task performance following genetic deletions of cannabinoid (CB1) receptor

Crombag, Hans S, Johnson, Alexander W, Zimmer, Anne M, Zimmer, Andreas and Holland, Peter C (2010) Deficits in sensory-specific devaluation task performance following genetic deletions of cannabinoid (CB1) receptor. Learning & Memory, 17 (1). pp. 18-22. ISSN 1072-0502

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Abstract

Cannabinoid CB1 receptor is abundantly expressed throughout the CNS and is implicated in numerous physiological and behavioral functions, including appetite and feeding. In the present study, wild-type and CB1 heterozygous and homozygous knockout mice were tested on an instrumental outcome-selective devaluation task to assess changes in acquired instrumental response levels for a distinct food reward following selective satiation. Deletion of CB1 receptor, as well as reduction in CB1 expression (HET), produced deficits in outcome-selective instrumental devaluation. These results identify a critical role for CB1 receptor in the ability of animals to represent, update, and/or use sensory-specific outcome representations to alter appetitive behaviors.

Item Type: Article
Schools and Departments: School of Psychology > Psychology
Depositing User: Hans Crombag
Date Deposited: 06 Feb 2012 15:43
Last Modified: 08 May 2012 13:53
URI: http://sro.sussex.ac.uk/id/eprint/14100
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