Radiation induced DNA damage responses

Jeggo, Penny and Löbrich, Markus (2006) Radiation induced DNA damage responses. Radiation Protection Dosimetry, 122 (1-4). pp. 124-127. ISSN 1742-3406

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Abstract

The amazing feature of ionising radiation (IR) as a DNA damaging agent is the range of lesions it induces. Such lesions include base damage, single strand breaks (SSBs), double strand breaks (DSBs) of varying complexity and DNA cross links. A range of DNA damage response mechanisms operate to help maintain genomic stability in the face of such damage. Such mechanisms include pathways of DNA repair and signal transduction mechanisms. Increasing evidence suggests that these pathways operate co-operatively. In addition, the relative impact of one mechanism over another most probably depends upon the cell cycle phase and tissue type. Here, the distinct damage response pathways are reviewed and the current understanding of the interplay between them is considered. Since DNA DSBs are the major lethal lesion induced by IR, the focus lies in the mechanisms responding to direct or indirectly induced DSBs.

Item Type: Article
Additional Information: GDSC181
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
Subjects: R Medicine > R Medicine (General)
Depositing User: Gee Wheatley
Date Deposited: 03 May 2007
Last Modified: 07 Mar 2017 06:35
URI: http://sro.sussex.ac.uk/id/eprint/1121
Google Scholar:45 Citations

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