The evolution of diverse biological responses to DNA damage: insights from yeast and p53

Wahl, G. M. and Carr, A. M. (2001) The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nature Cell Biology, 3. E277-E286. ISSN 1465-7392

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Abstract

The cellular response to ionizing radiation provides a conceptual framework for understanding how a yeast checkpoint system, designed to make binary decisions between arrest and cycling, evolved in a way as to allow reversible arrest, senescence or apoptosis in mammals. We propose that the diversity of responses to ionizing radiation in mammalian cells is possible because of the addition of a new regulatory control module involving the tumour-suppressor gene p53. We review the complex mechanisms controlling p53 activity and discuss how the p53 regulatory module enables cells to grow, arrest or die by integrating DNA damage checkpoint signals with the response to normal mitogenic signalling and the aberrant signalling engendered by oncogene activation.

Item Type: Article
Additional Information: GDSC1
Schools and Departments: School of Life Sciences
Subjects: Q Science > QP Physiology
Depositing User: Gee Wheatley
Date Deposited: 18 May 2007
Last Modified: 30 Nov 2012 16:51
URI: http://sro.sussex.ac.uk/id/eprint/1071
Google Scholar:320 Citations
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