CDC-25.1 regulates germline proliferation in Caenorhabditis elegans

Ashcroft, N. and Golden, A. (2002) CDC-25.1 regulates germline proliferation in Caenorhabditis elegans. Genesis, 33 (1). pp. 1-7. ISSN 1526-954x

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Abstract

Summary: The cell cycles in C. elegans are tightly controlled but appear to use the same regulators found in other organisms. Four homologues of the dual-specificity phosphatase Cdc25 are present in the C. elegans genome. In our study, we have characterized a deletion mutant for one of these orthologues. We show that embryonic defects are absent in cdc-25.1 homozygous mutants, presumably because of maternally contributed CDC-25.1 product. These embryos hatch and develop into sterile adults. The adults do not appear to have any somatic defects. The sterility results from inadequate germline proliferation. Germline precursors divide slowly and produce abnormally sized daughter cells. Only three to four rounds of germ-cell division occur before they die during the L3 and L4 larval stages. genesis 33:1-7, 2002.

Item Type: Article
Additional Information: GDSC19
Schools and Departments: School of Life Sciences
Subjects: Q Science > QP Physiology
Depositing User: Gee Wheatley
Date Deposited: 18 May 2007
Last Modified: 30 Nov 2012 16:51
URI: http://sro.sussex.ac.uk/id/eprint/1069
Google Scholar:24 Citations
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