Strange goings-on in the mouse germ line

Bridges, B. A. (2003) Strange goings-on in the mouse germ line. DNA Repair, 2 (11). pp. 1269-72. ISSN 1568-7864

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Abstract

It is a conventional paradigm that mutagens lead to changes in nucleotide sequence when the cell attempts to repair or replicate lesions in DNA (such as adducts or strand breaks) that have been produced by the mutagens or their metabolites. The resulting changes are located at (or very near) the sites of the initial damage. This is the underlying theory behind mutational spectra work, but how general is it in vivo? Work with ionising radiation has shown that there are interesting things going on in the mouse germ line that do not fall within the conventional paradigm. Mutations occur at certain sites remote from initial DNA damage and in greater than expected number. Bryn Bridges discusses some recent papers on mutational changes in the germ line of mice following exposure to chemical mutagens that suggest that such phenomena may not be confined to radiation.

Item Type: Article
Additional Information: 1568-7864 Journal Article Review GDSC128
Keywords: Alkylating Agents/toxicity Animals DNA Damage/*drug effects/radiation effects Dose-Response Relationship, Drug Ethylnitrosourea/toxicity Etoposide/toxicity Germ Cells/*drug effects/radiation effects Germ-Line Mutation/*drug effects/radiation effects Humans Male Mesylates/toxicity Mice Mutagens/toxicity Mutation Nucleic Acid Synthesis Inhibitors/toxicity Radiation, Ionizing Spermatogonia/*drug effects/radiation effects Tandem Repeat Sequences/drug effects
Depositing User: Gee Wheatley
Date Deposited: 02 Apr 2007
Last Modified: 13 Jun 2012 13:55
URI: http://sro.sussex.ac.uk/id/eprint/1033
Google Scholar:6 Citations
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