Caldecott, K. W. (2003) Protein-protein interactions during mammalian DNA single-strand break repair. Biochemical Society Transactions, 31 (Pt 1). pp. 247-51. ISSN 0300-5127Full text not available from this repository.
The genetic stability of living cells is continually threatened by endogenous reactive oxygen species and other genotoxic molecules. Of particular threat are the thousands of single-strand breaks that arise in each cell every day. If left unrepaired, such breaks can give rise to potentially clastogenic or lethal chromosomal double-strand breaks. This article summarizes our current understanding of how mammalian cells detect and repair single strand breaks, and provides insights into novel polypeptide components of this process.
|Depositing User:||Gee Wheatley|
|Date Deposited:||02 Apr 2007|
|Last Modified:||11 Jun 2012 08:54|
|Google Scholar:||46 Citations|