Protein-protein interactions during mammalian DNA single-strand break repair

Caldecott, K. W. (2003) Protein-protein interactions during mammalian DNA single-strand break repair. Biochemical Society Transactions, 31 (Pt 1). pp. 247-51. ISSN 0300-5127

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Abstract

The genetic stability of living cells is continually threatened by endogenous reactive oxygen species and other genotoxic molecules. Of particular threat are the thousands of single-strand breaks that arise in each cell every day. If left unrepaired, such breaks can give rise to potentially clastogenic or lethal chromosomal double-strand breaks. This article summarizes our current understanding of how mammalian cells detect and repair single strand breaks, and provides insights into novel polypeptide components of this process.

Item Type: Article
Additional Information: GDSC53
Depositing User: Gee Wheatley
Date Deposited: 02 Apr 2007
Last Modified: 11 Jun 2012 08:54
URI: http://sro.sussex.ac.uk/id/eprint/1032
Google Scholar:46 Citations
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